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Under different federal statutes, EPA makes a broad range of decisions to protect public health and the environment from unintended consequences of using chemicals. Decisions about chemicals are also made by other Federal Agencies, State Environmental and Health Agencies, International Governmental Agencies and Industry.
To help support these efforts, EPA researchers are integrating available chemical information including physicochemical properties, environmental fate and transport, exposure, usage, in vivo toxicity, and in vitro bioassay into an online tool called the Computational Toxicology (CompTox) Chemicals Dashboard, formerly the Chemistry Dashboard, to help decision-makers and scientists quickly and efficiently evaluate thousands of chemicals.
The Dashboard contains chemistry, toxicity and exposure information for over one million chemicals, with over 300 chemical lists based on structure or category. Data and models within the Dashboard also help with efforts to identify chemicals of most need of further testing and reducing the use of animals in chemical testing.
The Dashboard can be searched by chemical identifiers (e.g. DTXSID and CASRN), consumer product categories (i.e. view chemicals found in certain product types), and assays/genes associated with high-throughput screening data. Using high-throughput screening, living cells or proteins are exposed to chemicals and examined for subsequent changes that suggest potential biological responses. The advanced search function can be used to search chemicals based on their mass or molecular formula and batch searches can be performed based on chemical identifiers, MS-ready formulas, exact formulas and monoisotopic mass.
Bill Sanders, Ph.D., is an assistant professor in the Department of Pediatrics at the University of Southern California and a researcher within the CHOIR program, Saban Research Institute, Childrens Hospital Los Angeles. His research interests include homeless youth, injection drug use, club drug use, polydrug use, gang youth, youth violence, and general involvement in offending. He is currently an ethnographer and analyst on three-city study of the health risk surrounding the injection of ketamine and a principal investigator on a public health study of gang-identified youth in Los Angeles. Both studies are funded by the National Institute on Drug Abuse. His latest book, Drugs, Clubs and Young People: Sociological and Public Health Perspectives, was published in 2006 by Ashgate.
Stephen E. Lankenau, Ph.D., is an assistant professor at the University of Southern California, Keck School of Medicine, Departments of Pediatrics and Preventative Medicine. Trained as a sociologist, he has studied street-involved and other high-risk populations for the past 10 years, including ethnographic projects researching homeless panhandlers, prisoners, sex workers, and injection drug users. Currently, he is principal investigator of a 4-year NIH study researching ketamine injection practices among young IDUs in New York, New Orleans, and Los Angeles.
Jennifer Jackson Bloom received her MPH with a specialization in epidemiology from the University of California, Los Angeles. She works with the Division of Research on Children, Youth and Families at Childrens Hospital Los Angeles. Her research interests include behavioral risk in substance abusing populations, modeling longitudinal change in substance use and the application of geography to drug abuse research.
Dodi Hathazi graduated with a B.S. in psychology, magna cum laude, from Saint Lawrence University in Canton, New York. She works as an ethnographer with the Division of Research on Children, Youth and Families at Childrens Hospital Los Angeles. Her research interests include polydrug use patterns among homeless traveling youth and reproductive health issues including pregnancy rates and outcomes in high-risk youth. Previously, she worked at the RAND Corporation in Santa Monica, California, in the Survey Research Group where she collected data for three behavioral research projects.
Governments worldwide are committing more funding for scientific research in the face of the ongoing pandemic and climate crises. However, the funding process must be restructured to remove the barriers arising from conscious and unconscious biases experienced by minoritized groups, including women, and particularly women of colour.
The 2022 Nobel Prize in Chemistry has been awarded to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless for the development of click chemistry and bioorthogonal chemistry. In recognition of this award, Nature Portfolio presents a collection of research, review and opinion articles that focus on the origins, the development and the future directions inspired by the topic.
Nature Synthesis is open for submissions of original research articles. The journal will publish research, reviews and opinion articles on chemical and materials synthesis as well as enabling technological innovations.
The COVID-19 pandemic is causing significant disruption and we are very aware that many researchers will have difficulty in meeting the standard timelines for our peer-review process. Please let us know if you need additional time. Our systems will continue to remind you of the original deadlines but we will be highly flexible as required.
Research chemicals are chemical substances used by scientists for medical and scientific research purposes. One characteristic of a research chemical is that it is for laboratory research use only; a research chemical is not intended for human or veterinary use. This distinction is required on the labels of research chemicals, and is what exempts them from regulation under parts 100-740 in Title 21 of the Code of Federal Regulations (21CFR).[1]
Research chemicals are fundamental in the development of novel pharmacotherapies. Common medical laboratory uses include in vivo and animal testing to determine therapeutic value, toxicology testing by contract research organizations to determine drug safety, and analysis by drug test and forensic toxicology labs for the purposes of evaluating human exposure. Many pharmacologically active chemicals are sold online under the guise of \"research chemicals,\" when in reality they are untested designer drugs that are being sold for recreational use despite the compounds' transitional or unclear legal status.
Research agrochemicals are created and evaluated to select effective substances for use in commercial off-the-shelf end-user products. Many research agrochemicals are never publicly marketed. Agricultural research chemicals often use sequential code names.[2][3]
While many people buy research chemicals online thinking they are safe or harmless, they can be habit-forming and sometimes require addiction treatment. Depending on the type purchased and method of use, they have the potential to be extremely dangerous, causing users to become sick or possibly overdose.
The results of the analyses were compared with the information provided by the suppliers and the legality of the active ingredients ascertained. This information is summarised in table 1. Although methoxetamine was legal when the research was conducted, it was classified as a temporary class drug in March 2012, making its supply illegal.
The majority of products purchased (91%) provided information pertaining to the active ingredients present in each substance (either on the website or packaging, or both), although products purchased from three of the suppliers (A, B and D) did not adhere to the advertised ingredients. Out of the 22 products supplied and analysed, 9% did not list the active ingredients (Jolly Green Granules) and 23% did not contain the active ingredients listed on the website or package. Instead of containing 17-alpha,21-Dihydroxy-16-alpha-methylpregna-1,4,9(11)-triene-3,20-dione-21-acetate, both of the NRG-3 products contained benzofuran (1-benzofuran-6-ylpropan-2-amine). This suggests that the benzofuran mixture is being sold as a number of different products (benzofuran and NRG-3), thus supporting previous research.4 Benzofuran was found in 27% of the products, and although it is chemically similar to amphetamines and MDMA, there is little scientific information on its toxicity, its psychoactive properties or its effect on humans and their health. Instead of the advertised ingredients, benzocaine was found in three of the products (MDAI and both Jolly Green Granules). Benzocaine is a local anaesthetic and a popular cutting agent for cocaine. In contrast to earlier research,5 there were no traces of mephedrone in either of the Jolly Green Granules. However, both NRG-2 products contained 4-methylethcathinone (4-MEC) with a smaller, trace, amount of 4-methylmethcathinone (4-MMC) or mephedrone, possibly as an unwanted contaminant, making them illegal. By measuring the integrated intensities of the Proton NMR resonances,9 the relative concentration of 4-MEC was approximately 35 times that of 4-MMC. Consistent with the findings of Brandt et al,5 no other compounds were found in either NRG-2 samples. Therefore, the product being sold is of a high purity and the amount of illegal cathinone taken is simply the quantity of powder consumed.
These findings show illegal cathinones are still being sold online as legal alternatives to illegal substances, which was also a marketing tool used by all the suppliers in this research. Analogies were made between the substances for sale and the recently banned cathinone, mephedrone or illegal drugs like amphetamine, ecstasy (MDMA) or ketamine. 781b155fdc